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Traditionally, alveolar numbers have been thought to be largely complete at age 2 years, thereafter with alveoli increasing in measurement. Recent in vivo research utilizing hyperpolarised 3-helium MRI recommend that alveolar numbers enhance all through the interval of somatic development,21 confirmed by direct histological measurements in rhesus monkeys.22 Hyperpolarised 3-helium MRI studies suggest that alveolar quantity increases with ageing,23 notably within the apices and mid-zones.

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