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But lobbying by tobacco large Reynolds American, maker of the best-selling Vuse e-cigarette, has made some advocates hesitant about pushing the difficulty. With restricted sources, the FDA used "discretion" to delay choices on many applications, permitting products - including major manufacturers like Vuse - to stay on the market for years. Fourteen years later, the FDA hasn’t finalized manufacturing guidelines that might lengthen its authority to international vaping factories.

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